By Inge Scharrer, Wolfgang Schramm, G. Auerswald, A. Kurth, J. Oldenburg, W. Schramm, B. Zieger
This booklet comprises the contribution to the thirty sixth Hemophilia Symposium, Hamburg 2005. the most subject matters are epidemiolgy, hemophilia remedy, orthopedic therapy in hemophiliacs, hemostaseologic prognosis and pediatric hemostaseology. the amount is rounded off by means of a number of loose papers and posters on hemophilia, inhibitors in hemophilia and diagnostics.
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Additional resources for 36th Hemophilia Symposium Hamburg 2005: Epidemiology; Hemophilia Therapy - Management of Bleedings and Inhibitors; Orthopedic Treatment in Hemophiliacs; ... Pediatric Hemostaseology; Free Lectures
Increasing The Worldwide Supply Of Safe, Affordable Factor Replacement Therapy. 26 September 2005 – Fourth WFH Global Forum – Montreal, Canada 2. Evatt B. Guide to Developing a National Patient Registry. WFH 2005 3. Evatt BL, Black C, Batorova A, Street A, Srivastava A. Comprehensive care for hemophilia around the world. Hemophilia 2004;10 (Suppl 4):9–13. 4. Krebs H, Domsch C, Adelhard K, Brackmann HH, Graw J, Oldenburg J, Schwaab R, Schramm W. The national GTH hemophilia registry as database within the scope of the German human genome project.
14 14 12 10 8 8 6 4 4 2 2 0 <5 Giurgiu Bistrit¸a Vâlcea Teleorman Tulcea Mehedint¸i Ialomit¸a Caˇlaˇras¸i Bacaˇu Buzaˇu Braila Vrancea Gorj Dolj 5–10 Cluj Ias¸i Muret¸ Alba Arget¸ Dîmbovit¸a Vaslui Giurgiu Hunedoara Satu Mare Neamt¸ Prahova Bihor Saˇlaj 10–15 Botos¸ani Bras¸ov Caras¸ Constant¸a Galat¸i Maramures¸ Arad Olt 15–20 Bucures¸ti Sibiu Timis¸oara Suceava > 20 Covasna Harghita Fig. 1. Prevalence of hemophilia – territorial distribution The explanation of this large variation is that the disease is insufficiently recognized in different parts of the country, especially in non-university centers.
LRP Regions Responsible for Interaction with FVIII All members of the LDL receptor family are structurally similar and consist of intracellular, transmembrane and extracellular domains. The structure of LRP and LDLR involved in clearance of FVIII, as well as the structure of two other receptors, gp330 and VLDLR, which interact with FVIII, are shown in Figure 1. The structure of these receptors is similar. All of them contain homologous cysteine-rich complement type repeats of class A (CR), involved in ligand binding.
36th Hemophilia Symposium Hamburg 2005: Epidemiology; Hemophilia Therapy - Management of Bleedings and Inhibitors; Orthopedic Treatment in Hemophiliacs; ... Pediatric Hemostaseology; Free Lectures by Inge Scharrer, Wolfgang Schramm, G. Auerswald, A. Kurth, J. Oldenburg, W. Schramm, B. Zieger