By Dimitrios Linos (Editor), Jon A. van Heerden (Editor)
- Over 2 hundred beautiful illustrations, starting from intraoperative images, line drawings, diagnostic photographs, pathology slides, tables and graphs can be found to make every one case mentioned understandable and straightforward to follow. - conventional and novel ther
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Extra info for Adrenal Glands: Diagnostic Aspects and Surgical Therapy
Interestingly, a dual receptor system exists for glucocorticoids in the central nervous system, including the glucocorticoid receptor type I, or mineralocorticoid receptor, which responds to low levels of glucocorticoids and is primarily activational, and the classic glucocorticoid receptor (type II), which responds to higher levels of glucocorticoids and is dampening in some systems and activational in others . 1 HPA Axis: Immune System Over the last few decades compiling evidence has revealed a variety of interactions between the HPA axis and the immune system, suggesting an alliance of these systems against immune challenges.
This finding implicates the CRH gene and consequently the HPA axis as a potentially important target of ovarian steroids and a potential mediator of gender related differences in the stress response and HPA axis activity. 2 Growth Axis Growth is also sacrificed in order to preserve homeostasis under stressful conditions through a variety of inhibitory effects mediated by the HPA axis (Fig. Prolonged activation of the HPA axis results in increased circulating levels of glucocorticoids which suppress the secretion of growth hormone (GH) and inhibit the action of somatomedin C and other growth factors on their target tissues [15, 122, 57].
Can J Biochem Physiol 33:408–415 99. Salas MA, Evans SW, Levell MJ, et al (1990) Interleukin-6 and ACTH act synergistically to stimulate the release of corticosterone from adrenal gland cells. Clin Exp Immunol 79:470–473 100. Sanchez ER, Faber LE, Henzel WJ, et al (1990) The 56–59-kilodalton protein identified in untransformed steroid receptor complexes is a unique protein that exists in cytosol in a complex with both the 70 and 90 kilodalton heat shock proteins. Biochemistry 29:5145– 5152 101.
Adrenal Glands: Diagnostic Aspects and Surgical Therapy by Dimitrios Linos (Editor), Jon A. van Heerden (Editor)