By S. Sarantseva
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Additional info for Amyloidosis - Mechanisms and Prospects for Therapy
A pyrrolidine carboxylic acid derivative, which is a competitive inhibitor of SAP binding to amyloid fibrils, can intervene in this process and affect SAP levels. This compound cross-linked and dimerized SAP molecules, which led to extremely rapid clearance by the liver, and thus produced marked depletion of circulating human SAP. This drug action thus removed SAP from human amyloid deposits in tissues and may have a favorable effect on amyloidosis. Another compound, dimethyl sulfoxide (DMSO), is a hydrogen-bond disrupter, celldifferentiating agent, hydroxyl radical scavenger, cryoprotectant, and solubilizing agent that is used as a compound for preparation of samples for electron microscopy, as an intracellular low-density lipoprotein-derived cholesterol-mobilizing antidote to extravasation of vesicant anticancer agents, and as a topical analgesic.
And Fink, A. L. (2004). Annular oligomeric amyloid intermediates observed by in situ atomic force microscopy. J Biol Chem 279,23: 24452-9. , Souillac, P. , Carter, S. A. and Fink, A. L. (2002). Surfacecatalyzed amyloid fibril formation. J Biol Chem 277,52: 50914-22. 2 Amyloid A Amyloidosis Secondary to Rheumatoid Arthritis Tadashi Nakamura Kumamoto Center for Arthritis and Rheumatology, and Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan 1. Introduction Amyloids are insoluble fibrous protein aggregates sharing specific structural traits.
Shirasawa, H. (1995). A novel allelic variant of serum amyloid A, SAA1: genomic evidence, evolution, frequency, and implication as a risk factor for reactive systemic AA-amyloidosis. Human Molecular Genetics, Vol. 4, No. 6, (June 1995), pp. , Salvadori, M. & Immunopathology Group of the Italian Society of Nephrology (2008). Renal involvement in systemic amyloidosis: an Italian collaborative study on survival and renal outcome. Nephrology and Dialysis Transplantation, Vol. 23, No. 3, (March 2008), pp.
Amyloidosis - Mechanisms and Prospects for Therapy by S. Sarantseva